| 摘要 |
The invention relates to the field of medicine, and more particularly to producing an injectable form of a chondroitin sulphate (CS) preparation for the treatment of arthritic and rheumatic diseases, based on an Xa salt of chondroitin sulphate, which is a mucopolysaccharide from animal tissues. The method consists in preparing the ingredients of the injectable form of the preparation separately during production. More particularly: a chondroitin sulphate substance is dissolved in warmed injectable water. Next, solutions of benzyl alcohol and sodium hydroxide are prepared. Then, the benzyl alcohol and sodium hydroxide solutions and water for injection are added, under agitation, to the cooled sterile solution of CS. The resultant mixture is analyzed, the solution is adjusted according to the requirements of the manufacturer's monograph, sterilization filtration is carried out and the mixture is poured into 1 or 2 ml vials, which are then sealed. The technical result consists in replacing repeated intermediate sterilization filtration operations with terminal sterilization filtration, thereby making it possible to produce a preparation of the requisite quality while eliminating unnecessary expenditure in the production of the preparation. |
