Bicyclic nitrogen-containing aromatic heterocyclic amide compound

摘要

Compounds of formula (I) and salts thereof:;
wherein the variables are defined herein, are useful for the treatment of breast cancer.

主权项

1. A compound of the formula (I) or a salt thereof: wherein R1 is aryl or monocyclic nitrogen-containing heteroaryl, each of which is optionally substituted with at least one substituent selected from the group consisting of halogen, lower alkyl, —O-lower alkyl, halogeno-lower alkyl, —O-halogeno-lower alkyl, —CN, dimethylamino, and cycloalkyl; wherein X is CH, N, or C; is a single bond if X is CH or N or is a double bond if X is C; Y is a cyclic group of any of formulae Y-1 to Y-11: Y1 is CRh or N; Y2 is CRi or N; Y1 and Y2 are not both N; Ra, Rb, and Ri are each independently H or halogen; Rb is H or lower alkyl; Rc is lower alkyl; Y3 is CH or N; Rd and Re are each independently H or lower alkyl; Rf is H or lower alkyl; Y4 is O or S; Y5 is CH or N; Y6 is CH or N; Rg is H or lower alkyl; R2 is H or lower alkyl; and either R3 and R4 are each independently H, halogen, lower alkyl, —O-lower alkyl, halogeno-lower alkyl, —O-halogeno-lower alkyl, cycloalkyl, or —CN, or R3 and R4 form 2,2-difluoro-1,3-benzodioxole with the benzene ring to which R3 and R4 are bonded.