| 主权项 |
1. Compounds of formula (I) wherein: R1 is H or C1-C3 alkyl R2 is either halogen or X is either CH or N R3 is either C1-C3 alkyl or (1-methylpiperidin-4-yl) Rx and Ry are either H or nitro Rz and Rz′ are H, OH, or oxo Rt and R′t can be the same or different and are H or C1-C3 alkoxy Ra is H or F Rb is H, C1-C3 alkoxy, trifluoromethyl, or halogen Re is H or halogen Rf is H, C1-C3 alkyl or trifluoromethyl Rg is H or F Rk is H, halogen, trifluoromethyl, C1-C3 alkoxy, C1-C3 alkylsulfonamino Rl is H or F Rm is H, C1-C3 alkoxy, F or trifluoromethyl Rn is H, C1-C3 alkyl or a 5- to 6 -membered aromatic or heteroaromatic ring Rp is either C1-C3 alkyl or 5- to 6 -membered aromatic or heteroaromatic ring Rq is either H or tri(C1-C4)alkylsilyl Rs is tri(C1-C4)alkylsilyl Rh is either H , C1-C3 alkoxy or C1-C3 alkylcarbonylamino Ru is either H or F Rv is a C1-C3 alkyl Rw and Rw′ can be the same or different and are hydroxyl or C1-C3 alkoxy L and L′ are O, S, SO or SO2; Z is either C or N and pharmaceutically acceptable salts thereof. |
