| 摘要 |
1,175,639. N - (Alkyleneimino - isopropyl)- amino pyridine derivatives. FARBENFABRIKEN BAYER A.G. 25 Sept., 1968 [25 Sept., 1967], No. 45546/68. Heading C2C. The invention comprises novel N-(alkyleneimino - isopropyl) - arninopyridine derivatives of the Formula I wherein n is 6, 7 or 8, and X is H or COR<SP>111</SP>, wherein R<SP>111</SP> is H or an alkyl or alkenyl group of up to 4 C atoms and their acid addition salts. The compounds of the above Formula I wherein X is COR<SP>111</SP> are prepared by acylating the corresponding compounds of Formula I wherein X is H, the latter compounds being prepared either by alkylating the corresponding aminopyridine with the appropriate 1-alkyleneiminoisopropyl halide in the presence of sodium amide and separating the desired compound from the mixture of N-pyridyl-1-alkyleneimino- 2 - aminopropanes and N - pyridyl - 2 - alkyleneimino-1-aminopropanes produced, or by heating in the presence of copper bronze and K 2 CO 3 the corresponding halopyridine with the appropriate 1 - alkyleneimino - 2 - aminopropane, resulting from the reductive amination of the alkyleneiminoketone obtained by reacting chloroacetone with the appropriate alkyleneimino. Pharmaceutical compositions, having analgesic activity and suitable for oral, rectal and parenteral administration, contain compounds of Formula I in which X is COR<SP>111</SP> or acid addition thereof as the active ingredients in admixture with solid or liquid diluents or carriers.
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