摘要 |
Sulphonamides (I) and their base salts. - (I) R1,2 = H, 1-4C alkyl/alkoxy/alkyl-S - R3 = 1-8C alkyl/alkoxy, opt. cyclised and contng. other O atoms - R4 = H, 1-4C alkyl - X = O, N or S - Y = 1-4C alkyl - n = 0-4 2(4-(5-methylisoxazole-3-carboxamido)ethyl-benzenesulphamido) -5-i- -Bu (II)/n-BuO/i-PrO/MeOCH2CH2O-pyrimidine; 2(4-(5-methylisoxazole-3-carboxamido)methylbenzenesulphamido)-5-i- -Bu-pyrimidine; etc. - As hypoglycaemic agents - A mixt. of 2-(4-beta-aminoethylbenzenesulphamido) 5-i-butylpyrimidine (33 g), pyridine (100 ml) and 5-methyl-3-isoxazolecarboxylic chloride (16 g) is heated for 2 hrs. at 60 deg. to give (II) (30 g), m.p.223 deg. (methylglycol).
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申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
HORSTMANN,HARALD,DR.;PLUEMPE,HANS,DR.;PULS,WALTER,DR.;SCHROEDER,EBERHARD,DR.;GUTSCHE,KLAUS,DR.;LOGE,OLAF,DR. |