发明名称 |
Diagnostic reagents based on unique sequences within the variable region of the T cell receptor and uses thereof |
摘要 |
This invention provides a reagent capable of binding to T cells and having specificity for a unique sequence within the variable region of the beta chain of the T cell receptor, the presence of increased number of T cells carrying the unique sequence relative to the number of T cells carrying the sequence present in a normal subject being associated with a specific disease. Specific diseases such as human cancers, e.g. lymphomas; autoimmune diseases, e.g. rheumatoid arthritis; Alzheimer's disease; infectious diseases, e.g. those caused by bacteria, yeast or parasite; or allergies, may be diagnosed as follows. A suitable sample containing T cells is obtained from a subject. The sample is contacted under appropriate conditions with such a reagent. If the subject's cells contain the unique sequence, a detectable complex is formed between the reagent and T cells which contain the sequence. By quantitatively determining the number of T cells containing the sequence present in the complex formed and comparing this number with the number of T cells carrying the sequence determined for a normal subject, the disease with which the unique sequence is associated may be diagnosed. Similar reagents and methods may also be used to detect organ transplant rejection.
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申请公布号 |
US4886743(A) |
申请公布日期 |
1989.12.12 |
申请号 |
US19850726502 |
申请日期 |
1985.04.24 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
HOOD, LEROY E.;WEISSMAN, IRVING L.;MCGRATH, MICHAEL S. |
分类号 |
A61K38/00;C07H21/04;C07K14/00;C07K14/705;C07K14/725;C07K16/00;C07K16/28;C07K19/00;C12N15/00;C12N15/09;C12P21/08;C12Q1/68;G01N33/50;G01N33/53;G01N33/564;G01N33/569;G01N33/574;G01N33/576;G01N33/577 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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