| 摘要 |
PCT No. PCT/US88/03658 Sec. 371 Date Apr. 8, 1991 Sec. 102(e) Date Apr. 8, 1991 PCT Filed Oct. 18, 1988 PCT Pub. No. WO90/04393 PCT Pub. Date May 3, 1990.Certain enol ethers and esters of the formula <IMAGE> where X and Y are each hydrogen, fluoro or chloro; R1 is 2-thienyl or benzyl and R is alkanoyl, cycloalkylcarbonyl, phenylalkanoyl, chlorobenzoyl, methoxybenzyl, phenyl, thenoyl, omega-alkoxycarbonylalkanoyl, alkoxycarbonyl, phenoxycarbonyl, 1-alkoxyalkyl, 1-alkoxycarbonyloxyalkyl, alkyl, alkylsulfonyl, methylphenylsulfonyl or dialkylphosphonate are useful as prodrug forms the known 3-acyl-2-oxindole-1-carboxamide antiinflammatory and analgesic agents.
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