METHODS FOR PRODUCING HEMOGLOBIN PREPARATIONS AND PREPARATIONS OBTAINABLE THEREBY

摘要

This invention relates to a glutaraldehyde cross-linked and polymerized hemoglobin (polyHbXl), which possesses the property of reversibly binding gaseous ligands such as oxygen and is useful for transporting and supplying oxygen to vital tissues and organs. This product is produced in such a way that administration of the modified hemoglobin solution prevents toxic hemorrhagic disorders which normally occur with a glutaraldehyde polymerized hemoglobin solution.