| 摘要 |
A 2,6,9-trisubstituted purine composition having the following formula: <IMAGE> where X is a amino, oxo, thio, of sulfone moiety, R1 is a lower alkyl, substituted lower alkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, aryl, substituted aryl, heterocycle, hetaryl, substituted hetaryl, aralkyl, heteroaralkyl, heteroalkyl, alkyl alkenyl, alkyl alkynyl, alkyl cycloalkyl, or alkyl cycloheteroalkyl, each having from 1 to 20 carbon atoms; R2 is hydrogen, lower alkyl, substituted lower alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heterocycle, hetaryl, substituted hetaryl, aralkyl, heteroaralkyl, heteroalkyl, alkyl alkenyl, alkyl alkynyl, alkyl cycloalkyl, or alkyl cycloheteroalkyl; and R3 is halogen, hydroxyl, thio, alkoxy, alkylthio, lower alkyl, -NR4R5 or a component having the formula: <IMAGE> wherein when R3 is 2-hydroxyethylamino and R2 is methyl, R1-X is not amino, 3-methyl-2-butenylamino, benzylamino, or m-hydroxybenzyl-amino, when R3 is 2-hydroxyethylamino and R2 is isopropyl, R1-X is not benzylamino, m-hydroxybenzylamino, or 3-methylbutylamino, when R3 is 2-hydroxyethylamino and R2 is 2-hydroxyethyl, R1-X is not benzylamino and when R3 is selected from the group consisting of 2-propanol-2-methylamino and 2-dimethylaminoethylamino and R2 is methyl, then R1-X is not benzylamino. |
