NONCLASSICAL ANTIFOLATES

摘要

2-Amino-4-hydroxy-4,5,6,7-tetrahydropyrido¢2,3-d!pyrimidine derivatives of aromatic amides, such as a benzamide or thienylcarboxamide in which the amino portion of the amide is other than L-glutamic acid are inhibitors of enzymes which utilize folic acid, in particular glycinamide ribonucleotide formyl transferase. A typical embodiment is N-(N-{4-¢2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido¢2,3-d!pyrimidin-6-yl)ethyl!benzoyl}-L-.gamma.-glutamyl)-D-aspartic acid.