发明名称 |
SIMULATED ACTIVITY OF PROTEIN A DISPLAYED BY LIGANDS ATTACHED TO A CELLULOSE BEAD SURFACE |
摘要 |
A method and compound for the purification of proteins including the attachment of a non-peptidic, small compound which simulates the affinity of Protein A for immunoglobulins to a support matrix. Once attached on the support matrix, the resulting monochloro-triazine derivative is reacted with an excess of an amino compound at a higher temperature to achieve high level s of substitution. The resulting support matrix with ligand is useful in the affinity separations of antibodies. Further, a mercapto heterocyclic system ligand may be attached to the super matrix and useful in affinity separation s of antibodies.
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申请公布号 |
CA2407276(A1) |
申请公布日期 |
2001.11.08 |
申请号 |
CA20012407276 |
申请日期 |
2001.04.30 |
申请人 |
ACCURATE POLYMERS, INC. |
发明人 |
STIPANOVIC, BOZIDAR;GRIFFIN, MARTIN;SCARPA, IOANNIS |
分类号 |
B01J20/32;C07K1/22;C07K16/02;C07K16/06;(IPC1-7):B01J20/32 |
主分类号 |
B01J20/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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