发明名称 |
Transdermal administration of ACE inhibitors |
摘要 |
Disclosed is a dermal composition comprising enalapril ethyl ester or another prodrug corresponding to a pharmaceutically active form of an ACE inhibitor in an amount corresponding to a therapeutically effective amount of enalaprilat (or other pharmaceutically active form of enalapri) or pharmaceutically active form of the ACE inhibitor in admixture with a pharmaceutically acceptable carrier. In a preferred embodiment, the carrier is a pressure-sensitive adhesive matrix comprising a polymer or polymer blend. The dermal composition is applied in a method of substantially increasing the flux of enalaprilat through the skin of a human or an animal by maintaining the dermal composition in contact with the skin.
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申请公布号 |
US6805878(B2) |
申请公布日期 |
2004.10.19 |
申请号 |
US20010014785 |
申请日期 |
2001.12.14 |
申请人 |
NOVEN PHARMACEUTICALS, INC. |
发明人 |
LI CHENSHENG;NGUYEN VIET |
分类号 |
A61K9/70;A61K31/40;A61K31/401;A61K47/10;A61K47/30;A61K47/32;A61K47/34;A61P9/04;A61P9/10;A61P9/12;A61P13/12;A61P43/00;(IPC1-7):A61F13/00;A61F13/02;A61L15/16 |
主分类号 |
A61K9/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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