发明名称 |
POLYMER CONJUGATES OF BOX-A OF HMGB1 AND BOX-A VARIANTS OF HMGB1 |
摘要 |
The present invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A) or of a biologically active fragment of HMGB1 Box-A. Further, the invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A). Moreover, the present invention concerns the use of said polymer conjugates of polypeptide molecules of HMGB1 Box-A to diagnose, prevent, alleviate and/or treat pathologies associated with extracellular HMGB1 and/or associated with an increased expression of RAGE. |
申请公布号 |
EP2068935(A1) |
申请公布日期 |
2009.06.17 |
申请号 |
EP20070818168 |
申请日期 |
2007.09.14 |
申请人 |
CREABILIS THERAPEUTICS S.P.A. |
发明人 |
TRAVERSA, SILVIO;LORENZETTO, CHIARA;MAINERO, VALENTINA;MORENA, SEBASTIANO;FUMERO, SILVANO;BECCARIA, LUCA |
分类号 |
A61K47/48;A61M25/00;C07K14/47;C07K14/52 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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