Bispecific chimeric proteins comprising DARPins

摘要

A bispecific chimeric protein including a designed ankyrin repeat protein (DARPin), and an IgG antibody, an scFv-Fc antibody fragment, or a combination thereof, linked to the DARPin; a method for treating or preventing cancer using the same; and related methods and compositions.

主权项

1. A bispecific chimeric protein comprising:
(a) anti-epidermal growth factor receptor (EGFR) DARPins, and (b) an anti-c-Met IgG antibody or a dimeric anti-c-Met scFv-Fc antibody fragment; wherein the C-terminus of each Fc region of the anti-c-Met IgG antibody or the dimeric anti-c-Met scFv-Fc antibody fragment is linked to one or more anti-EGFR DARPins.