| 摘要 |
The invention relates to novel caged ceramide 1-phosphate (C1P), caged ceramide 1-phosphate derivatives(C1P), and the method of using them for delivering C1P intracellularly in vitro and in vivo, for research and therapeutic purposes. Therapeutic purposes include treatment of diseases associated with cell death, such as neurodegerative diseases, including Alzheimer's disease. The disclosed compositions may also be used for wound healing. |
| 主权项 |
1. A D-erythro ceramide-1-phosphate derivative represented by formula 1, R1 represents the benzhydryl derivative of formula 2; R3 represents H or the benzhydryl derivative of formula 2 ; n is 12 or 14 R2 represents the fatty acyl group of formula 4 R4 represents H or OH; R5 represents a saturated or unsaturated aliphatic group of 12-22 carbon atoms; Y and Z independently represent H, Cl, Br, OH, OCH3, or triazolyl, in which case at least one of Y or Z represents OH; or Y and Z on together to form a 5 or 6 member carbocyclic or heterocyclic ring that is optionally fused to a second 5 or 6 member carbocyclic or heterocyclic ring, wherein the second 5 or 6 member carbocyclic or heterocyclic ring is optionally fused to a third 5 or 6 member carbocyclic or heterocyclic ring, and wherein any of the carbocyclic or heterocyclic rings are optionally substituted with one or more functional groups selected from the group consisting of methyl, OH, OCH3, Cl, Br, NO2, NMe2, and NEt2; Ar1 represents phenyl, or phenyl substituted with one or more functional groups selected from the group consisting of NMe2, NEt2, OH, and OCH3. |
