发明名称 |
TARGETED MODIFICATION OF RAT GENOME. |
摘要 |
Compositions and methods are provided for modifying a rat genomic locus of interest using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as described herein. Compositions and methods for generating a genetically modified rat comprising one or more targeted genetic modifications in their germline are also provided. Compositions and methods are provided which comprise a genetically modified rat or rat cell comprising a targeted genetic modification in the rat interleukin-2 receptor gamma locus, the rat ApoE locus, the rat Rag2 locus, the rat Rag1 locus and/or the rat Rag2/Rag1 locus. The various methods and compositions provided herein allows for these modified loci to be transmitted through the germline. |
申请公布号 |
MX2015014487(A) |
申请公布日期 |
2016.07.28 |
申请号 |
MX20150014487 |
申请日期 |
2014.04.16 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
GEORGE D. YANCOPOULOS;DAVID M. VALENZUELA;JEFFREY D. LEE;ALEXANDER O. MUJICA;WOJTEK AUERBACH;KA-MAN VENUS LAI |
分类号 |
C12N15/85 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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