发明名称 |
IMPLANTABLE MEDICAL DEVICE WITH BENEFICIAL AGENT CONCENTRATION GRADIENT |
摘要 |
An implantable medical device comprises: an implantable device body having a mural surface (26) and a luminal surface (24) and a plurality of holes (20) traversing both the mural and luminal surface; a therapeutic agent, a matrix (40), and a barrier layer (30) contained in each of the plurality of holes; wherein the holes each have a luminal opening and a mural opening and the barrier layer is positioned across the luminal opening, and the therapeutic agent is primarily delivered through the mural opening of the hole; wherein the therapeutic agent is present in both the barrier layer and the matrix, at different local concentrations, and the matrix is created in a stepwise manner, such that a concentration gradient of the therapeutic agents exists in the matrix. |
申请公布号 |
EP2289571(B1) |
申请公布日期 |
2016.08.03 |
申请号 |
EP20100010594 |
申请日期 |
2004.03.29 |
申请人 |
INNOVATIONAL HOLDINGS, LLC |
发明人 |
PARK, KINAM;SHANLEY, JOHN F.;PARKER, THEODORE L. |
分类号 |
A61L29/08;A61K31/337;A61L27/34;A61L29/16;A61L31/04;A61L31/10;A61L31/12;A61L31/16 |
主分类号 |
A61L29/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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