| 发明名称 | Growth differentiation factor 11 (GDF-11) for treatment of diastolic heart failure | ||
| 摘要 | The technology described herein relates to treatments for, e.g., diastolic heart failure, cardiac hypertrophy, and related conditions. | ||
| 申请公布号 | US9434779(B2) | 申请公布日期 | 2016.09.06 |
| 申请号 | US201314385578 | 申请日期 | 2013.03.11 |
| 申请人 | The Brigham and Women's Hospital, Inc.;President and Fellows of Harvard College | 发明人 | Lee Richard T.;Loffredo Francesco;Pancoast James;Steinhauser Matthew;Wagers Amy |
| 分类号 | A61K38/00;A61K38/16;A61K38/17;A61K38/18;C07K14/51;C07K14/71;A61K31/7088 | 主分类号 | A61K38/00 |
| 代理机构 | Nixon Peabody LLP | 代理人 | Nixon Peabody LLP |
| 主权项 | 1. A method of treating an age-related cardiac hypertrophy, the method comprising administering to a mammalian subject a composition comprising a mammalian GDF11 polypeptide, whereby the composition increases the level of Growth Differentiation Factor 11 (GDF11) polypeptide in the subject; and wherein the composition is administered intraperitoneally; intravenously; subcutaneously: intra-arterially; or intra-coronary arterially. | ||
| 地址 | Boston MA US | ||