| 发明名称 |
Antigen binding proteins |
| 摘要 |
The present invention relates to antigen binding proteins, such as antibodies, which bind to serum amyloid P component (SAP), polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present invention also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with amyloid deposition including systemic amyloidosis, local amyloidosis, Alzheimer's disease, and type 2 diabetes. |
| 申请公布号 |
US9434716(B2) |
申请公布日期 |
2016.09.06 |
| 申请号 |
US201113037505 |
申请日期 |
2011.03.01 |
| 申请人 |
Glaxo Group Limited |
发明人 |
Bhinder Tejinder Kaur;Ford Susannah Karen;Germaschewski Volker;Lewis Alan Peter;Pepys Mark Brian |
| 分类号 |
C07K16/00;C07D403/06;C07K16/18;A61K39/00 |
主分类号 |
C07K16/00 |
| 代理机构 |
|
代理人 |
Fedon Jason C.;Han William T. |
| 主权项 |
1. A humanised antibody, comprising SEQ ID NO:1 (CDRH1), SEQ ID NO:2 (CDRH2), SEQ ID NO:3 (CDRH3), SEQ ID NO:4 (CDRL1), SEQ ID NO:5 (CDRL2), and SEQ ID NO:6 (CDRL3), which binds to serum amyloid P component (SAP). |
| 地址 |
GB |
