| 摘要 |
1,272,337. Basic carbamates. KNOLL A.G. CHEMISCHE FABRIKEN. 20 Oct., 1970 [26 Nov., 1969], No. 49667/70. Heading C2C. Novel carbamates of the general Formula I: wherein R 1 is wherein X is methylene or ethylene and Y and Z are the same or different C 1-4 alkyl or aralkyl groups or together form an alkylene residue and R 2 is hydrogen or methyl or R 1 and R 2 together with the carbon atom attached thereto is a cyclic residue having one or two tertiary nitrogen atoms and salts thereof may be prepared by reacting 2.phenylbicyclo[2.2.1]heptane-2-carbonic acid chloride with sodium azide to form the azide, decomposing the azide to the isocyanate and reacting the isocyanate with an amino-alcohol II: Pharmaceutical compositions of the compounds I with the usual excipients show high spasmolytic, anticholinergic, broncholitic and nicotinolytic properties when administered orally or parenterally. |
