| 摘要 |
FIELD: organic chemistry. SUBSTANCE: invention describes compounds of the formula (I): $$$ where: $$$ and $$$ each means hydrogen or alkyl; or $$$ and $$$ taken together form the group of the formula $$$ where k - the whole number; $$$ means hydrogen, alkyl, alkoxy, halogen or hydroxy; A and B each means hydrogen, alkyl, aralkyl, aliphatic carboxylic acyl, aryl-substituted aliphatic carboxylic acyl, aromatic carboxylic acyl or carbamoyl; or A and B taken together form groups: $$$, -C(=O)-C(=O)-, $$$ or $$$; X means group of the formula $$$ where W is aryl or heterocyclic group; $$$ is a simple bond, oxygen or sulfur or $$$ where $$$ means hydrogen, alkyl, aralkyl or aryl and m = 0 or the whole number; Y means group of the formula $$$ where $$$ is a simple bond, oxygen or sulfur and n - the whole number; Z means heterocycle, and their salts, esters, solvates and prodrug precursors that can be used for treatment and/or prophylaxis, for example, hyperlipemia, hypoglycemia, obesity, insufficient tolerance to glucose, insulin-resistance and diabetic complications. EFFECT: improved method of synthesis, enhanced effectiveness. |
