摘要 |
<p>Pyridine derivatives represented by general formula (1) and salts thereof, and medicines containing the same as the active ingredient, such as a cytokine production inhibitor, wherein R?1 and R2¿ represent each H, alkyl, cycloalkyl, hydroxyalkyl, optionally substituted alkoxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, optionally substituted aralkyl, phenacyl or acyl; R3 represents alkyl, optionally substituted phenyl, heteroaryl or cyclic amino; and X represents O or a combination of OH with H. These compounds have potent and highly specific and safe immune function regulating effects capable of suppressing excessive production of specified cytokines in various immunologic diseases.</p> |