| 摘要 |
<p>The inventive subject matter described herein provides complexes comprised of tissue factor bound to a phospholipid vesicle. The phospholipid vesicle can comprise 1,2-dioleyl-sn-glycero-3-phosphocholine (DOPC) and 1-palmitoyl-2-oleyl-sn-glycero-3-phosphoserine (POPS), and have a diameter of about 200 nm to about 300 nm, for example. The vesicles can be unilamellar, and the complex can comprise a multiple number of molecules of tissue factor (preferably 10 or more) bound to the phospholipid vesicle. Optionally, the vesicles also can have thrombomodulin bound thereto. Methods of using the complexes and preparations comprising these complexes are also provided herein.</p> |
