Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents)

摘要

The invention provides compounds of formula (I): wherein: R² and R³ independently represent various substituents; R¹ and R⁴ independently represent H, F, Cl, Br, C_1-2alkyl, C₁alkoxy, OH, CN, or NO₂; B represents a sulfur atom or a -CH₂-group; t represents 3 or 4; and A represents an optionally substituted 5- or 6-membered aromatic heterocyclic ring, or an optionally substituted bicyclic heterocyclic ring system in which at least the ring bound to the group B in Formula (I) is aromatic; or a salt thereof. Preferably, A is selected from one of the groups (i), (ii) or (iii): wherein X¹ and X² are independently N or CR⁸, and X³ is NR⁸, O or S; Y¹ and Y³ are independently N or CR⁹, and Y² is NR⁹, O or S; Z¹ is NR¹⁰, O or S, and Z² and Z³ are independently N or CR¹⁰; R⁸, R⁹, and R¹⁰ are as herein defined, and R⁷ is H, a halogen atom, OH, cyano, nitro, C_1-4alkyl, C_1-4alkoxy, C_1-4alkylenedioxy, C_1-4alkanoyl, or C_1-4alkylsulfonyl, an optionally substituted 3-, 4-, 5- or 6-membered cycloalkyl ring, or a group of the formula (a), (b), (c) or (d) as defined by the formulas (a), (b), (c) or (d). The compounds are modulators of dopamine D₃ receptors and have potential in the treatment of psychotic conditions (e.g. schizophrenia) or substance abuse.