| 摘要 |
PROBLEM TO BE SOLVED: To industrially and advantageously obtain a compound useful as an intermediate for dyes, a medicine and an agrochemical, etc., in high yield by reacting a nitrogen-containing heteroaromatic ester compound with specific amines in the presence of a Lewis acid. SOLUTION: A nitrogen-containing heteroaromatic ester compound of formula I (X is an atomic group capable of forming a 5,6-membered heteroaromatic ring; R<1> is an alkyl) is reacted with amines of formula II (R<2> and R<3> are each H, an alkyl, an aryl, a heterocyclic group, etc.) in a Lewis acid to provide the objective nitrogen-containing aromatic amides of formula III. The Lewis acid is preferably used in an amount of 0.0005-0.35 equivalent based on amines of formula II. For example, ethyl picolinate, aniline and aluminum chloride are stirred under nitrogen atmosphere to provide picolinic anilide. |
