发明名称 |
DNA COMPOSITION FOR ELICITING AN IMMUNE RESPONSE AGAINST TUMOR-ASSOCIATED MACROPHAGES |
摘要 |
The present invention provides a DNA composition comprising a DNA minigene construct that encodes for a polypeptide comprising a plurality of immunogenic fragments of a cysteine endopeptidase that is expressed in tumor-associated cells. The immunogenic fragments are joined together serially by a linker peptide between each successive fragment in the polypeptide. The polypeptide is capable of eliciting an immune response against the tumor-associated cells, is expressible in immune cells, and is incorporated in a pharmaceutically acceptable carrier. |
申请公布号 |
EP2069378(A2) |
申请公布日期 |
2009.06.17 |
申请号 |
EP20070867206 |
申请日期 |
2007.10.05 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
REISFELD, RALPH, A.;XIANG, RONG;LUO, YUNPING |
分类号 |
C12N9/64;A61K39/00;C12N9/50 |
主分类号 |
C12N9/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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