发明名称 |
BTK INHIBITORS TO TREAT SOLID TUMORS THROUGH MODULATION OF THE TUMOR MICROENVIRONMENT |
摘要 |
In certain embodiments, the invention includes therapeutic methods of using a BTK inhibitor to treat solid tumor cancers by modulation of the tumor microenvironment, including macrophages, monocytes, mast cells, helper T cells, cytotoxic T cells, regulatory T cells, natural killer cells, myeloid-derived suppressor cells, regulatory B cells, neutrophils, dendritic cells, and fibroblasts. |
申请公布号 |
WO2016087994(A1) |
申请公布日期 |
2016.06.09 |
申请号 |
WO2015IB59100 |
申请日期 |
2015.11.24 |
申请人 |
ACERTA PHARMA B.V. |
发明人 |
HAMDY, AHMED;ROTHBAUM, WAYNE;IZUMI, RAQUEL;LANNUTTI, BRIAN;COVEY, TODD;ULRICH, ROGER;JOHNSON, DAVE;BARF, TJEERD;KAPTEIN, ALLARD |
分类号 |
A61K31/00;A61K31/4155;A61K31/416;A61K31/4439;A61K31/454;A61K31/4985;A61K31/519;A61K39/395;A61K45/06;A61P35/00 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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