MANIPULATION AND DETECTION OF PROTEIN PHOSPHATASE 2C - PP2C ALPHA - EXPRESSION IN TUMOR CELLS FOR CANCER THERAPY, PREVENTION AND DETECTION

摘要

A method of detecting cancer in a patient by detecting alteration of activity of the gene coding for human type protein phosphatase 2C (PP2C&agr; and PP2C&bgr;) and genetic polymorphisms thereof in a specimen isolated from the patient is disclosed. The invention further provides a method of treating cancer including the steps of first determining the type of cancer and cells expressing the cancer and then preparing a vector which will specifically target the cancer cells and can include regulatory, elements to control the expressibility of PP2C&agr;. The vector is then administered to the patient. Alternatively an antisense vector can be prepared.