| 摘要 |
Aminopropanol derivs. of formula (I) and their physiologically acceptable salts are new. In (I), R1 and R2 are H, lower alkyl (opt. substd. by OH or alkanoyloxy), or COZ; X is OH, alkoxy or NR6R7; R6 and R7 are H or lower alkyl or hydroxyalkyl; R3 is H or OR8; R8 is H, lower alkanoyl or aroyl opt. substd. by halo lower alkyl or alkoxy, alkoxycarbonyl, OH, alkylthio, CN, NO2 or CF3; R4 and R5 are H, halo, OH, lower alkyl, alkoxy or alkylthio, COOH, benzyloxy, benzyloxycarbonyl or alkoxycarbonyl; X and Y are N or -C(R9)=; R9 is H, lower alkyl opt. substd. by OR8, or COZ. (I) are vasodilators (hypotensives) and inhibitors of beta-adrenergic receptors. In an example, 4- 2-hydroxy-3-(4-phenoxymethylpiperidino)propoxy indole was prepd. from 4-(2,3-epoxypropoxy)indole and 4-phenoxymethyl-piperidine. |
