Monoclonal antibodies to drugs, methods for their production and somatic cell hybridomas secreting them.

摘要

A monoclonal antibociy to a drug, usually a haptenic drug of molecular weight between about 100 and 1500 daltons such as gentamicin, produced by somatic cell hybridization. Lymphocytes which produce antibodies to the drug are fused with myeloma cells to form hybridomas, a hydridoma clone which secretes the desired antibody is isolated by conventional procedures, and the secreted monoclonal antibodies are harvested.