METHODS AND COMPOSITIONS FOR PRODUCING MORPHOGEN ANALOGS
摘要
The invention disclosed herein provides methods and compositions for the computer-assisted design of morphogen analogs. Practice of the invention is enabled by the use of at least a portion of the atomic co-ordinates defining the three-dimensional structure of human osteogenic protein-1 (hOP-1) as a starting point in the design of the morphogen analogs. In addition, the invention provides methods for producing morphogen analogs of interest, and methods for testing whether the resulting analogs mimic or agonize human OP-1-like biological activity. The invention also provides a family of morphogen analogs produced by such methods.
申请公布号
WO9726277(A2)
申请公布日期
1997.07.24
申请号
WO1997US01071
申请日期
1997.01.22
申请人
CREATIVE BIOMOLECULES, INC.;BRANDEIS UNIVERSITY
发明人
KECK, PETER;GRIFFITH, DIANA, L.;CARLSON, WILLIAM, D.;RUEGER, DAVID, C.;SAMPATH, KUBER, T.