发明名称 |
MODIFIED PROTEIN AND PEPTIDE PHARMACEUTICALS |
摘要 |
<p>"Partial" and "complete" CTP units are used to modify biologically active proteins and peptides to alter their clearance patterns. "Complete" CTP units have the amino acid sequence found at positions 112-118 to position 145 of the beta -subunit of human chorionic gonadotropin; "partial" CTP units are missing at least one amino acid in the region of position 118-145 inclusive. Variants of these CTP units contain 1-5 conservative amino acid substitutions which do not destroy activity. Suitable peptides or proteins which may be modified in this manner include various hormones and cytokines.</p> |
申请公布号 |
GR3032775(T3) |
申请公布日期 |
2000.06.30 |
申请号 |
GR20000400477T |
申请日期 |
2000.02.28 |
申请人 |
WASHINGTON UNIVERSITY |
发明人 |
BOIME, IRVING |
分类号 |
A61K38/00;A61K38/22;A61K38/24;C07K14/59;C07K14/62;(IPC1-7):C07K1/00;A61K38/27;C12N15/00;C07K14/00;A61K38/08 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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