| 摘要 |
A compound of the following formula: (see fig. I) and its pharmaceutically acceptable salt thereof, wherein R1 and R~ are independently hydrogen, C1-4 alkyl, C3-7 cycloalkyl, C2-4 alke nyl,C1-4 alkoxy-C1-4 alkyl, C1-4 alkylthio-C1-4 alkyl, p henyl, phenyl-C1-4alkyl, halo-substituted C1-4 alkyl, C3-7 cycloalkyl-C1-3 alkyl or hydroxy-C1-4alkyl ; or R1 and R~ are taken together with the nitrogen to which they are attached and form optionally substituted, saturated or unsaturated 3-, 4-, 5-, 6- or 7- member ed heterocyclic containing one to two heteroatoms, provided that the heterocycl ic is not pyrrolidinyl; R3 is hydrogen, C1-4 alkyl or a hydroxy protecting group; Ar is optionally substituted phenyl or phenyl-C1-3 alkyl; and X is optionally substituted phenyl, naphthyl, biphenyl, indanyl, benzofuran yl, benzothiophenyl, 1-tetralone-6-yl, C1-4 alkylenedioxy, pyridyl, furyl or thienyl. These compounds and pharmaceutical compositions containing them are useful as analgesic, antiinflammatory, diuretic, antitussive, anesthetic or neuroprotective agents, or an agent for treatment of stroke or functional bo wel disease such as abdominal pain, for the treatment of a mammalian subject, especially a human subject.
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