INTERACTION INHIBITORS, METHOD OF DETECTING INTERACTION INHIBITOR AND KIT FOR DETECTING INTERACTION INHIBITOR

摘要

It is intended to provide an inhibitor of an interaction between proteins, which relates to the regulation of T cell activity, IL-2 production and so on, a method of detecting the interaction inhibitor, etc. Namely, an inhibitor of an interaction between PKCtheta and KPNA1 and an inhibitor of an interaction between KPNA1 and NF-kappaB are provided. Such an interaction inhibitor is detected by making candidate compounds to coexist with two proteins interacting with each other under such conditions as allowing the interaction of the corresponding combination, examining whether or not the interaction occurs, and a regarding a candidate compound inhibiting the interaction as an inhibitor. A detection kit which contains a sample supplying the combination of proteins interacting with each other.