发明名称 |
Autoinducer synthase modulating compounds and uses therefor |
摘要 |
Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifying modulators of the autoinducers synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can be used for therapeutic treatment of bacterial infections particularly in immunocompromised subjects. They are also useful in treating disease states associated with autoinducer synthesis and biofilm development.
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申请公布号 |
EP1834645(A1) |
申请公布日期 |
2007.09.19 |
申请号 |
EP20060010040 |
申请日期 |
1999.07.29 |
申请人 |
UNIVERSITY OF IOWA RESEARCH FOUNDATION |
发明人 |
CRONAN, JOHN E., JR.;PLAPP, BRYCE V.;GREENBERG, E. PETER;PARSEK, MATTHEW R. |
分类号 |
A61K31/70;A61K31/7076;C07H19/16;C07H19/167;C07H19/20;C07H19/207;C12N9/00;C12P21/02;C12Q1/25;G01N33/68 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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地址 |
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