发明名称 |
Methods for detecting Corpuscles of Stannius protein stanniocalcin |
摘要 |
The present invention relates to human Corpuscles of Stannius polypeptides and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antagonists against such polypeptides. Human Corpuscles of Stannius protein inhibits calcium uptake and reduces renal excretion of phosphate. Also provided is a diagnostic assay to detect mutations in the nucleic acid sequence encoding the polypeptide and for altered concentrations of the polypeptide in a sample derived from a host.
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申请公布号 |
US7326537(B2) |
申请公布日期 |
2008.02.05 |
申请号 |
US20050076158 |
申请日期 |
2005.03.10 |
申请人 |
HUMAN GENOME SCIENCES, INC. |
发明人 |
OLSEN HENRIK S.;ADAMS MARK D. |
分类号 |
C12N15/09;G01N33/53;A61K35/12;A61K35/76;A61K38/00;A61K39/395;A61K48/00;A61P3/00;A61P3/02;A61P43/00;C07H21/04;C07K14/47;C07K14/56;C07K14/575;C07K16/18;C07K16/26;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/99;C12N15/12;C12P21/02;C12P21/08;C12Q1/68;C12R1/19 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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