| 摘要 |
There are created human neural blastoma cells inductively expressing various forms of the -synuclein, a protein involved in the infrequent and hereditary Parkinson's disease and other synucleinopathetic disorders. Differentiated as to a neural phenotype by use of retinoic acid and expressing, likewise, the -synuclein, said cells exhibit: pathologic accumulation of soluble oligomeric -synuclein, accumulation of cytoplasmatic synuclein inclusion bodies, lysosomal disfunction, proteasomal disfunction, and cellular death. These cells presenting the above characteristics are liable to be used as cell models of the Parkinson's disease and other synucleinopathetic disorders as well as to constitute the basis for the mass random control of various pharmaceutical or other substances used as potential therapies for these neurodegenerative diseases. |
