发明名称 |
NEW ANTIVIRAL SUBSTITUTED PYRIMIDINEDIONE HOMOCARBOCYCLIC NUCLEOSIDE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME AS ACTIVE INGREDIENTS |
摘要 |
The present invention relates to novel compound of general formula (I) and pharmaceutically acceptable salts thereof, and process for the preparation of such derivatives and to pharmaceutical compositions containing the same as active ingredients, wherein R1, R2 and R3 represent independently hydrogen atom, halogen atom, C1-C10 alkyl, C1-C10 thioalkyl, C3-C8 optionally substituted cyclicalkyl, unsaturated alkyl, substituted alkyl hydroxyl or aryl hydroxyl, C1-C10 alkylamine, nitro, C1-C4 lower ester, C1-C4 lower alkoxy, C1-C4 lower thioalkoxy; Z represents oxygen atom, sulfur atom, carbon atom and carbonyl group; X represents oxygen atom, sulfur atom; n represents an integer of 1-3; and (sub)cycloalk(en)yl represents (a) or (b), in which (a) represents (c), (d), (e), or (f) in which R4 and R5 represent independently hydrogen atom, hydroxymethyl, protected hydroxymethyl, benzyl, substituted carbonyl, substituted alkylsulfonyl or arylsulfonyl, substituted silyl or the like. |
申请公布号 |
WO9730979(A1) |
申请公布日期 |
1997.08.28 |
申请号 |
WO1996KR00265 |
申请日期 |
1996.12.30 |
申请人 |
SAMJIN PHARMACEUTICAL CO., LTD.;CHO, EUI-HWAN;CHUNG, SUN-GAN;KIM, JOONG-YOUNG;KWON, HO-SEOK;LEE, SUN-HWAN;LEE, JAE-EUNG;JOO, JEONG-HO;KIM, BYUNG-CHUL;KANG, DONG-WOOK |
发明人 |
CHO, EUI-HWAN;CHUNG, SUN-GAN;KIM, JOONG-YOUNG;KWON, HO-SEOK;LEE, SUN-HWAN;LEE, JAE-EUNG;JOO, JEONG-HO;KIM, BYUNG-CHUL;KANG, DONG-WOOK |
分类号 |
A61K31/505;A61K31/506;A61K31/695;A61P31/12;A61P31/14;A61P31/18;C07D239/54;C07D239/60 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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