| 摘要 |
<p>Targeted cytotoxic T lymphocytes have a TcR comprising heterologous 'alpha' and 'beta' polypeptides, which heterologous polypeptides confer on the lymphocyte MHC Class I-restricted specificity for disease-causing target cells. The lymphocytes may be monovalent, having a single species of TcR conferring specificity for a single class of target cells. The lymphocytes find application as vaccines and in adoptive immunotherapy, e.g. cancer, AIDS or antiviral therapy.</p> |
