Therapeutic compositions comprising imidazole and imidazolium compounds

摘要

Therapeutic compositions comprising substituted imidazole or imidazolium compounds may be used for a number of medical purposes, such as treatment of undesirable conditions or diseases, including disease or conditions related to bone, cancer, and/or pain.

主权项

1. A method of treating knee pain comprising orally administering a dosage form to a mammal in need thereof, wherein the dosage form comprises: in an amount that is less than 0.1% w/w, and greater than 0% w/w; or in an amount that is less than 0.1% w/w, and greater than 0% w/w; wherein any amount in % w/w is based upon the total weight of Compound A, Compound B, and Compound C; wherein each A is independently an acidic functional group; wherein, if present, the bioavailability of zoledronic acid in the dosage form is from about 1.1% to about 4%.