| 主权项 |
1. A method of treating or reducing the likelihood of a disease involving abnormal cell proliferation, the method comprising administering, to a subject in need of such treatment, a therapeutically effective amount of a compound of formula (I): or a dinuclear or polynuclear form thereof, wherein Z is iridium or rhodium X is a halo or donor ligand; each R1-R5 is independently H, methyl, a substituted or unsubstituted alkyl or alkenyl, an aryl, a substituted or unsubstituted saturated or unsaturated cyclic or heterocyclic ring, NH2, NO2, OR1, COOR1; with the proviso that at least one of said R1-R5 groups is selected from a substituted or unsubstituted alkyl or alkenyl, an aryl, a substituted or unsubstituted saturated or unsaturated cyclic or heterocyclic ring, NH2, NO2, OR1, or COOR1; wherein R1 is a C1-C6 alkyl or alkenyl, an aryl, a saturated or unsaturated cyclic or heterocyclic ring, or a trimethylsilyl; L-L′ is a chelating ligand; Q is an ion and is either present or absent; and M and n are charges, independently either absent or selected from a positive or negative whole integer, or solvates or prodrugs thereof with the proviso that when R1 -R5 are each independently methyl, then L and L′ are not each independently N or O; wherein the disease is a cancer selected from carcinoma of the bladder, breast, or colon, colon adenocarcinoma and colon adenoma, kidney, epidermal, liver, lung, adenocarcinoma, small cell lung cancer and non-small cell lung carcinomas, oesophagus, gall bladder, ovary, pancreas, exocrine pancreatic carcinoma, stomach, cervix, thyroid, prostate, or skin, squamous cell carcinoma, leukemia, acute lymphocytic leukemia, B-cell lymphoma, T-cell lymphoma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, hairy cell lymphoma, or Burkett's lymphoma, acute and chronic myelogenous leukemias, myelodysplastic syndrome, or promyelocytic leukemia, thyroid follicular cancer, fibrosarcoma or habdomyosarcoma, astrocytoma, neuroblastoma, glioma or schwannoma, melanoma, seminoma, teratocarcinoma, osteosarcoma, xenoderoma pigmentoum, keratoctanthoma, thyroid follicular cancer, or Kaposi's sarcoma. |
