| 摘要 |
1,183,781. 6 - Phenyl - 2,3,5,6 - tetrahydroimidazo[2,1-b]thiazole. IMPERIAL CHEMICAL INDUSTRIES Ltd. 13 Jan., 1969 [14 Feb., 1968], No. 7321/68. Heading C2C. Optical resolution of the title compound (I) is effected by a process comprising treating its solution in an organic solvent with an arenesulphonyl derivative of L-pyroglutamic acid, or a diaroyl derivative of (+)-tartaric acid, the concentrations of the reactants being such that the corresponding (+)- or (-)-I salt crystallizes directly from the solvent. Specifically claimed per se are salts of (+)-I with N-p-toluenesulphonyl - L - pyroglutamic acid (II), N - benzenesulphonyl - L - pyroglutamic acid and di - p - toluoyl - (+) - tartaric acid (III); and of (-)-I with II, N-(naphthalene-1-sulphonyl)- L-pyroglutamic acid, dibenzoyl-( + )-tartaric acid and III. |
