N{HU 6{B -Substituted-9-{8 3-(4-phenyl-piperazino)-propyl{9 -adenines

摘要

A N6-substituted-9-[3-(4-phenyl-piperazino)-propyl]-adenine of the formula (I) wherein R1 is hydrogen or a lower alkyl radical, and R2 is a lower alkyl radical, a lower alkyl radical substituted by at least one of phenyl and hydroxyl, a lower alkenyl radical, a cycloalkyl radical or an aryl radical, or R1 and R2 together with the nitrogen atom to which they are attached form a piperidine, pyrrolidine or morpholine ring, and R3 is hydrogen, halogen, a lower alkyl radical or a lower alkoxy radical, OR A SALT THEREOF WITH A PHARMACOLOGICALLY COMPATIBLE ACID, WHICH COMPOUNDS ARE CHARACTERIZED BY MARKED ANTI-EDEMATOUS ACTIVITY AS WELL AS BY ACTIVITY IN REDUCING CAPILLARY PERMEABILITY.