1-Substituted-3-arylthio-4-hydroxypyrrolidines

摘要

Trans isomers of 1-substituted-3-arylthio-4-hydroxypyrrolidines and derivatives thereof having the formula: <IMAGE> are disclosed wherein R1 is hydrogen, lower-alkyl, -C(O)NH-lower-alkyl and -C(O)-NH-phenyl; R2 is lower-alkyl, cycloalkyl and phenylalkyl; Ar is phenyl and substituted phenyl and the pharmaceutically acceptable addition salts thereof. The compounds have antidepressant activity in animals.