| 摘要 |
NEW MATERIAL:A 5-hydroxyindole-3-carboxylic acid amide compound shown by formula I (R<1>-R<4> are H, alkyl, aryl, aralkyl or heteroaryl or R<1> and R<2> ore R<3> and R<4> together with neighboring N are bonded to form heterocyclic ring; R<5> is alkyl; R<6> is H, alkyl, cycloalkyl, aryl or aralkyl; X is H, halogen or lower alkanoyl) or an acid addition salt thereof. EXAMPLE:4-( 5-Hydroxy-2-methyl-4-piperidinomethylindol-3-ylcarbonyl )-morpholi ne. USE:A diuretic or a remedy for circulatory diseases. PREPARATION:For example, a compound shown by formula II is subjected to Mannich reaction to give a compound shown by formula I wherein X is H.
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