| 摘要 |
<p>The present invention relates to new benzopyranes having the formula I: <CHEM> wherein: R<1> and R<2> represent, among others, hydrogen, halogen, cyano, C1-4 alkyl, C1-4 alkoxy; R<3> is hydrogen or C1-4 alkyl, and R<4> is C1-4 alkyl, or R<3> and R<4> together form a C2-5 polymethylene chain; R<5> represents hydroxyl or acetoxy and R<6> is hydrogen, or R<5> together with R<6> form a carbonyl group and R<7> is hydrogen, or R<5> and R<6> together form a bond; R<7> is hydrogen or C1-6 alkyl; R<8> is a totally saturated C5-C6 cyclic or heterocyclic group selected from cyclopentyl, cyclohexyl, pyrrolidinyl, piperidinyl, piperazinyl, imidazolinyl, pyrazolidinyl, isothiazolidinyl, isoxazolidinyl, thiazolidinyl, oxazolidinyl or morpholinyl, which may be optionally substituted by one or two R<9> groups; R<9> is hydroxyl, oxo, C1-6 alkyl, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 alkoxycarbonylmethyl C1-6 alkylaminocarbonyl, R<1><0>-oxycarbonyl or R<1><0>-(C1-4)alkoxycarbonyl, wherein R<1><0> is an optionally substituted aryl or heteroaryl group. The invention also relates to a procedure for their preparation and to pharmaceutical compositions containing them. These compounds are antihypertensive and bronchodilator agents.</p> |
