发明名称 |
COMPOSITIONS FOR EXPRESSION OF PROTEINS IN HOST CELLS USING A PREPROCOLLAGEN SIGNAL SEQUENCE |
摘要 |
Hybrid genes comprising a nucleotide sequence encoding a preprocollagen signal sequence operatively linked to a nucleotide sequence encoding a heterologous protein are disclosed. The hybrid genes are useful for secretion of heterologous proteins from host cells. In a preferred embodiment, the signal sequence of the human preprocollagen alpha 1(I) protein is linked to a heterologous protein of interest to allow for secretion of the protein from Hansenula polymorpha cells.
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申请公布号 |
WO9639529(A1) |
申请公布日期 |
1996.12.12 |
申请号 |
WO1996US09035 |
申请日期 |
1996.06.06 |
申请人 |
BASF AG |
发明人 |
MANKOVICH, JOHN, A.;HAMMILL, LINDA, D.;FERENZ, CATHERINE, R. |
分类号 |
C07K14/78;C07K14/815;C12N15/79;(IPC1-7):C12N15/79;C12N15/62;C12N15/15;C12N15/12;C12N5/10;C12N1/19 |
主分类号 |
C07K14/78 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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