| 摘要 |
A labelled biotin cpd., of formula(I), and the cpd. being labelled with a metal atom selected from (a) 99m-Tc, 203Pb, 66Ga, 67Ga, 68Ga, 72As, 111In, 114mIn, 97Ru, 62Cu, 64Cu, 52Fe, 52mMn, 51Cr, 186Re, 188Re, 77As, 90Y, 67Cu, 169Er, 117mSn, 121Sn 127Te, 142Pr, 143Pr, 198Au, 199Au, 149Tb, 121Tb, 109Pd, 165Dy, 149Pm, 151Pm 153Sm, 157Gd, 166Ho, 172Tm, 169Yb, 175Yb, 177Lu, 105Rh and 111Ag, or (b) the paramagnetic metal atoms G, Mn, Fe, Co, Ni, Cu, Pr, Nd, Sm, Yb, Gd, Tb, Dy, Ho and Er, the metal atom being attached to the biotin cpd. by means of the chelating gp., is new. n is 1 or 2; R is a chelating gp. for chelating a metal atom; Sp is a spacing gp. having at least 4 atoms spacing NH from R. |
