| 摘要 |
PROBLEM TO BE SOLVED: To obtain a glycerophosphate dehydrogenase inhibitor containing an extract of white birch, having high safety and useful for the prevention and treatment of obesity. SOLUTION: White birch belonging to the genus Betula, family Betulaceae is extracted with water and/or an organic solvent and the extract is used as an active component. The extraction is carried out e.g. by extracting finely cut white birch chips with water, ethanol, etc., at refluxing temperature for 0.5-8hr or immersing the chips in water, ethanol, etc., at room temperature to 50 deg.C for 1-10 days. The inhibitor contains the active component in an amount of 0.3-15wt.% for oral administration and 0.01-10wt.% for parenteral administration. It is administered at a daily rate of 0.5-5,000mg for adult and 0.5-3,000mg for child in terms of the active component. The inhibitor may be compounded to a food in an amount of 0.001-15wt.%, preferably 0.01-10wt.% and used as a food composed mainly of cereal flour or starch such as bread, noodle, biscuit, hot cake or tablet candy, a dressing, a drink, etc. |
