发明名称 |
AQUEOUS LIQUID PREPARATION HAVING IMPROVED INTRAOCULAR GATIFLOXACIN PENETRATION |
摘要 |
An object is to provide an ophthalmic aqueous liquid preparation excellent in the retention of gatifloxacin in a tear fluid and the penetration of gatifloxacin into an aqueous humor and a conjunctiva. Another object is to prevent the formation of any precipitate and the reduction in viscosity in the aqueous liquid preparation. An aqueous liquid preparation comprising gatifloxacin, a pharmacologically acceptable salt thereof or a hydrate of gatifloxacin or the salt and at least 0.15 w/v% of xanthan gum enables to improve the retention and penetration of gatifloxacin. When at least 0.2 w/v% of sodium chloride is added to the aqueous liquid preparation, the formation of any precipitate and the reduction in viscosity in the aqueous liquid preparation can be prevented. |
申请公布号 |
WO2008044733(A1) |
申请公布日期 |
2008.04.17 |
申请号 |
WO2007JP69846 |
申请日期 |
2007.10.11 |
申请人 |
KYORIN PHARMACEUTICAL CO., LTD.;SENJU PHARMACEUTICAL CO., LTD.;SAWA, SHIROU |
发明人 |
SAWA, SHIROU |
分类号 |
A61K31/496;A61K9/08;A61K47/02;A61K47/36;A61P27/02;A61P31/04 |
主分类号 |
A61K31/496 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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